Biology Faculty Articles

Document Type

Article

Publication Date

9-4-2020

Publication Title

International Annals of Science

Keywords

14-3-3 proteins, 14-3-3 isoforms, YWHA, Mammalian reproduction, Gametogenesis

ISSN

2456-7132

Volume

10

Issue/No.

1

Abstract

The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein) is an acidic and homologous protein family involved in regulation of key biological events including cell cycle, signal transduction and development. They are highly conserved and are expressed ubiquitously across a wide variety of species ranging from plants to animals. Seven isoforms of 14-3-3 exist in mammals, which are encoded by separate genes, have tissue-specific, developmental stage-specific as well as isoform-specific presence and consequences. It is known that these proteins play significant roles in mitosis of mammalian cells and meiosis of amphibians. However, their effects on development and functioning of mammalian gonads and germ cells are not entirely delineated. This paper, for the first time, provides a comprehensive review of the comparative expression, localization/distribution, binding interactions, and importance of the 14-3-3 proteins in gametogenesis and reproduction among multiple female and male mammalian species. Thorough understanding of these proteins in oogenesis and spermatogenesis would help elucidate the physiological basis of fertility in mammals, including humans.

Comments

©2020 Santanu De.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Author(s) retains full copyright of their article and grants non-exclusive publishing right to International Annals of Science and its publisher “AIJR (India)”. Author(s) can archive pre-print, post-print and published version/PDF to any open access, institutional repository, social media or personal website provided that Published source must be acknowledged with citation and link to publisher version.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

ORCID ID

0000-0002-9739-4039

ResearcherID

L-6078-2019

DOI

10.21467/ias.10.1.52-59

Peer Reviewed

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