Theses and Dissertations

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Defense Date

6-1980

Document Type

Thesis - NSU Access Only

Department

Oceanographic Center

First Advisor

Joel Warren

Second Advisor

Barbara B. Jacobs

Abstract

A group of interrelated studies from these laboratories have shown that various cell-mediated and humoral immune processes were altered in rodents exposed to prolonged hyperbaric oxygen. The study here reported is based upon these findings and was undertaken to determine whether hyperoxygenemia would suppress cell-mediated rejection of foreign tissues and acceptance of xenogeneic tumor transplants. A Fischer 344 rat lymphoma (NRL 1871) was implanted intraperitoneally into C57BL/6, DBA/2 and BALB/c mice. Implants produced fatal neoplasms in 13 of 43 C57BL/6 and 6 of 18 DBA/2 mice given daily HBO for 30· days starting one day after implantation. None of the 17 BALB/c recipients given the same regimen of oxygen developed tumors nor did 117 untreated, tumor recipients observed over a period of 60 to 100 days. The xenogeneic growths metastasized extensively even after cessation of HBO therapy. The histologic appearance of these growths was identical with that of the parent lymphoma and they could be transplanted back to Fischer 344 rats but not to normal or HBO treated mice syngeneic with the primary xenogeneic host.

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