Ascomycota, Candida albicans, Leukemia P388, Microbial Sensitivity Tests, Pyrroles, Molecular Structure
Journal of Natural Products
As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.
Park, Young Chul, Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, and Amy E. Wright. "Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico." Journal of natural products 69, no. 4 (2006): 580-584.