Document Type

Article

Publication Date

2006

Publication Title

Journal of Natural Products

Keywords

Ascomycota, Candida albicans, Leukemia P388, Microbial Sensitivity Tests, Pyrroles, Molecular Structure

ISSN

0163-3864

Volume

69

Issue/No.

4

First Page

580

Last Page

584

Abstract

As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.

Comments

©2006 American Chemical Society and American Society of Pharmacognosy

ORCID ID

0000-0002-1637-4125

ResearcherID

F-8809-2011

DOI

10.1021/np058113p