Event Title

MECHANISTIC ANALYSIS OF VITAMIN B6 DEFICIENCY FOLLOWING SMALL BOWEL TRANSPLANTATION

Location

Auditorium A

Start Date

14-2-2014 12:00 AM

Description

Objective. This study was conducted to determine the cause of vitamin B6 deficiency reported following small bowel transplantation. Background. Earlier research has shown that patients following small bowel transplantation developed a vitamin B6 deficiency regardless of vitamin intake or supplementation. Methods. . For this study the urinary metabolite of vitamin B6 4-pyridoxic acid was measured in urine and compared to a matched healthy control subjects. Plasma Alkaline phosphatase, serum albumin and selected cytokines (IL-1², IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-±, IFN-³) were measured. Results. Twelve hour urinary 4-PA amounts were significantly higher in transplant group (16.92 μmol±3.58). Compared to the control group (1.11 μmol± 0.13) (p-value < 0.05). 4-PA amounts were (1.11 μmol ±0.13), (23.78 μmol ±5.96), and 10.1 μmol ±1.4) in control, transplant session 1 and transplant session 2, respectively. (pvalue < .05). Average alkaline phosphatase (ALKP) was (56.8 IU/L ±3.7) for control group and (112.5 IU/L ±18.4) for transplant group (p-value = 0.007). Average serum Albumin was (4.0 g/dl ±0.14) in the control group and (3.4 g/dl ±0.08) in the transplant group (p-value =0.001). Only IL-6 and TNF-± were significantly higher in transplant patients in both session 1 and 2 than in control group. Both IL-8 and IL-10 were significantly higher than in control during transplant session 1 only. The rest of the cytokines were not significantly different from control group. ANOVA was used for analysis Conclusion. The higher urinary 4-PA amounts seen in the transplant groups may indicate increased degradation. Elevated alkaline phosphatase plasma and decreased serum albumin in transplant patients may lead to increased P5P degradation. Grants. None

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Feb 14th, 12:00 AM

MECHANISTIC ANALYSIS OF VITAMIN B6 DEFICIENCY FOLLOWING SMALL BOWEL TRANSPLANTATION

Auditorium A

Objective. This study was conducted to determine the cause of vitamin B6 deficiency reported following small bowel transplantation. Background. Earlier research has shown that patients following small bowel transplantation developed a vitamin B6 deficiency regardless of vitamin intake or supplementation. Methods. . For this study the urinary metabolite of vitamin B6 4-pyridoxic acid was measured in urine and compared to a matched healthy control subjects. Plasma Alkaline phosphatase, serum albumin and selected cytokines (IL-1², IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-±, IFN-³) were measured. Results. Twelve hour urinary 4-PA amounts were significantly higher in transplant group (16.92 μmol±3.58). Compared to the control group (1.11 μmol± 0.13) (p-value < 0.05). 4-PA amounts were (1.11 μmol ±0.13), (23.78 μmol ±5.96), and 10.1 μmol ±1.4) in control, transplant session 1 and transplant session 2, respectively. (pvalue < .05). Average alkaline phosphatase (ALKP) was (56.8 IU/L ±3.7) for control group and (112.5 IU/L ±18.4) for transplant group (p-value = 0.007). Average serum Albumin was (4.0 g/dl ±0.14) in the control group and (3.4 g/dl ±0.08) in the transplant group (p-value =0.001). Only IL-6 and TNF-± were significantly higher in transplant patients in both session 1 and 2 than in control group. Both IL-8 and IL-10 were significantly higher than in control during transplant session 1 only. The rest of the cytokines were not significantly different from control group. ANOVA was used for analysis Conclusion. The higher urinary 4-PA amounts seen in the transplant groups may indicate increased degradation. Elevated alkaline phosphatase plasma and decreased serum albumin in transplant patients may lead to increased P5P degradation. Grants. None