College of Osteopathic Medicine Faculty Articles

Title

Induction of Forward Mutations at the Thymidine Kinase Locus of Mouse Lymphoma Cells: Evidence for Electrophilic and Non-electrophilic Mechanisms

ISBN or ISSN

0027-5107

Publication Title

Mutation Research

Volume

397

Issue

2

Publication Date / Copyright Date

2-1-1998

DOI Number

10.1016/S0027-5107(97)00231-5

Abstract

A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK±) locus in L5178Y mouse lymphoma cells was analyzed for structure–activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological mechanisms, these studies suggest that such mutations may occur by more than one mechanism. As might be expected, there was evidence for a component involving direct electrophilic attack on the cellular DNA, in a manner previously established as causative in the induction of mutations in Salmonella. In addition, however, there was also strong evidence for another mechanism or mechanisms involving chromosome missegregation, cellular toxicity or an alternate site of action, such as the microtubules.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

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Peer Reviewed

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