Faculty Articles
Title
Induction of Forward Mutations at the Thymidine Kinase Locus of Mouse Lymphoma Cells: Evidence for Electrophilic and Non-electrophilic Mechanisms
ISBN or ISSN
0027-5107
Publication Title
Mutation Research
Volume
397
Issue
2
Publication Date / Copyright Date
2-1-1998
DOI Number
10.1016/S0027-5107(97)00231-5
Abstract
A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK±) locus in L5178Y mouse lymphoma cells was analyzed for structure–activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological mechanisms, these studies suggest that such mutations may occur by more than one mechanism. As might be expected, there was evidence for a component involving direct electrophilic attack on the cellular DNA, in a manner previously established as causative in the induction of mutations in Salmonella. In addition, however, there was also strong evidence for another mechanism or mechanisms involving chromosome missegregation, cellular toxicity or an alternate site of action, such as the microtubules.
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
NSUWorks Citation
Henry, Barbara; Grant, Stephen G.; Klopman, Gilles; and Rosenkranz, Herbert S., "Induction of Forward Mutations at the Thymidine Kinase Locus of Mouse Lymphoma Cells: Evidence for Electrophilic and Non-electrophilic Mechanisms" (1998). Faculty Articles. 995.
https://nsuworks.nova.edu/hpd_com_faculty_articles/995
