College of Osteopathic Medicine Faculty Articles

Title

Neurocognitive aspects of medication adherence in HIV-positive injecting drug users

ISBN or ISSN

1090-7165

Publication Title

AIDS and Behavior

Volume

10

Issue

3

Publication Date / Copyright Date

5-1-2006

First Page

287

Last Page

297

Publisher

Springer Science + Business Media

DOI Number

10.1007/s10461-005-9062-6

Abstract

Cognitive deficits are associated with nonadherence to HIV medications. HIV-positive injecting drug users (IDUs) are at particular risk for nonadherence and cognitive barriers to adherence specific to this population should therefore be identified. The present study assessed the relation of three domains of cognitive functioning, executive functions, memory, and psychomotor speed, to self-reported antiretroviral adherence in a sample of HIV-positive IDUs. Depression, use of alcohol, heroin, cocaine/crack, or marijuana in the last week were also included in the models. Logistic regression analyses showed that only psychomotor slowing was significantly associated with nonadherence. Executive functions, memory, depression, and active alcohol and substance use were unrelated to adherence. No other studies to date have exclusively linked psychomotor slowing to nonadherence in HIV infection. Psychomotor slowing among our study sample was severe and suggests that when evident, such slowing may be a valuable determinant for antiretroviral adherence among IDUs.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

Keywords

Adult, Alcoholism, Anti-Retroviral Agents, Cognition Disorders, Depression, Diagnostic and Statistical Manual of Mental Disorders, Female, HIV Infections, Humans, Male, Motivation, Neuropsychological Tests, Patient Compliance, Psychomotor Disorders, Questionnaires, Severity of Illness Index, Substance Abuse, Intravenous