Influence of depression and HIV serostatus on the neuropsychological performance of injecting drug users.
ISBN or ISSN
Psychiatry and clinical neurosciences
Publication Date / Copyright Date
Depression is common in injecting drug users (IDUs), a group at significant risk for HIV infection. Moreover, both HIV infection and depression have been shown to adversely effect neurocognitive abilities. Understanding the effects of depression and HIV infection on the neurocognitive functioning of drug users is essential for appropriate management and/or treatment of these deficits in this population. Therefore, the purpose of the present study was to investigate the effects of depression and HIV status on cognitive functioning in 100 male and female IDUs. Participants were categorized into three groups of depression severity based on their scores on the Beck Depression Inventory: no depression, mild depression, and moderate to severe depression. The effects of depression and HIV serostatus as well as their interaction were assessed. Results indicated that regardless of serostatus, those with moderate to severe depression had lower scores on cognitive measures. These findings suggest that although depression contributes to poor neuropsychological performance in IDUs, this effect was not exacerbated by HIV infection. The finding also illustrates the importance of addressing depression-related neurocognitive deficits in IDUs.
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Adolescent, Adult, Cognition, Depressive Disorder, Diagnosis, Dual (Psychiatry), Ethnic Groups, Factor Analysis, Statistical, Female, Florida, HIV Seronegativity, HIV Seropositivity, Humans, Male, Middle Aged, Neuropsychological Tests, Sex Characteristics, Socioeconomic Factors, Substance Abuse, Intravenous, Viral Load
Waldrop-Valverde, Drenna; Ownby, Raymond L.; and Kumar, Mahendra, "Influence of depression and HIV serostatus on the neuropsychological performance of injecting drug users." (2005). College of Osteopathic Medicine Faculty Articles. 66.