College of Osteopathic Medicine Faculty Articles

Title

Accumulation of D-Aspartic Acid with Age in the Human Brain

Publication Title

Science

Volume

220

Issue

4604

Publication Date / Copyright Date

6-1-1983

First Page

1407

Last Page

1408

Abstract

An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

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