College of Osteopathic Medicine Faculty Articles

Title

Prevalence and correlates of Capgras syndrome in Alzheimer's disease.

ISBN or ISSN

0885-6230

Publication Title

International journal of geriatric psychiatry

Volume

14

Issue

6

Publication Date / Copyright Date

6-1-1999

First Page

415

Last Page

420

Abstract

OBJECTIVES: This study examined the prevalence and clinical correlates of Capgras syndrome (CS) in Alzheimer's disease.

DESIGN: Cross-sectional study of elderly patients evaluated at an outpatient memory disorders clinic classified according to the presence or absence of CS.

SUBJECTS: One hundred and fifty-one consecutive patients diagnosed with probable (N=110) or possible (N=48) Alzheimer's disease (AD) utilizing NINCDS-ADRDA diagnostic criteria.

MATERIALS: The Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Mini-Mental State Examination (MMSE) and Blessed Dementia Scale (BDS).

RESULTS: CS was observed in 10% of the sample (N=16). Associated factors included other delusions, lower MMSE scores and higher BDS scores. The relation between CS and both cognitive and functional status remained significant after controlling for other delusions.

CONCLUSION: CS was prevalent in approximately 10% of our community-dwelling AD sample. This syndrome was more common at the later stages of the illness and showed relations with increased functional impairment and other psychotic symptomatology.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

Keywords

Aged, Aged, 80 and over, Alzheimer Disease, Capgras Syndrome, Cognition Disorders, Cross-Sectional Studies, Delusions, Disease Progression, Female, Humans, Incidence, Male, Outpatients, Prevalence, Psychiatric Status Rating Scales

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