College of Osteopathic Medicine Faculty Articles

Title

Computational model of obsessive-compulsive disorder: examination of etiologic hypothesis and treatment strategies.

ISBN or ISSN

1091-4269

Publication Title

Depression and Anxiety

Volume

8

Issue

3

Publication Date / Copyright Date

1-1-1998

First Page

91

Last Page

103

Abstract

Research has shown that obsessive compulsive disorder (OCD) is related to structural and functional abnormalities in the brain, and several authors have organized these findings into theories of OCD neuropsychiatric dysfunction. In this paper, these theories were used to develop a neural network model of OCD. OCD symptoms were hypothesized to result from a hyperactive orbitofrontal-striato-thalamic-orbitofrontal neural loop. The network was constructed and trained with a backpropagation algorithm, and it was then used to assess etiologic theories of OCD (e.g., basal ganglia dysfunction, inadequate dopaminergic inhibitory influence on basal ganglia and excessive input from the limbic system). The network was also observed in analogues of the treatment of OCD with serotonergic medications and behavior therapy. Results show that a) the network behaved both normally and abnormally, depending on what combinations of perceptual, motivational, and neurochemical inputs were presented to it; b) several etiologic mechanisms produced changes in the networks' behaviors similar to patients' subjective experiences of OCD symptoms; and c) different treatment strategies, both those modeled as pharmacologic and behavioral therapies, produced reductions in simulated OCD symptoms.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

Keywords

Algorithms, Analysis of Variance, Basal Ganglia, Behavior Therapy, Brain Diseases, Cerebral Cortex, Chi-Square Distribution, Computer Simulation, Drug Therapy, Combination, Humans, Limbic System, Models, Neurological, Nerve Net, Neural Inhibition, Neural Networks (Computer), Obsessive-Compulsive Disorder, Raphe Nuclei, Serotonin Uptake Inhibitors, Thalamus

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