Decreased natural cell-mediated cytotoxicity per effector cell in acquired immunodeficiency syndrome
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Natural cell-mediated cytotoxicity (CYT) was determined using whole blood samples from 32 patients with the acquired immunodeficiency syndrome (AIDS) and 12 with AIDS-related complexes (ARC) and correlated with the number of putative natural killer cells (NK) bearing surface marker Leu 11a. Mean percent cytotoxicity (%CYT) was significantly lower in AIDS and ARC patients compared to that of normal controls. Mean %NK cells in AIDS patients was significantly higher than in normal, while %NK cells in ARC patients did not differ significantly from that of normal. In contrast, the absolute number of NK (NNK) cells in AIDS patients did not differ significantly from that of normal, while the NNK cells in ARC patients was significantly lower than those in normal. When the data were expressed in kinetic lytic units per NK cell (KLU/NK = maximum number of K562 cells killed per NK cell in 4 hours), significantly lower KLU/NK were observed in both AIDS and ARC patients compared to that in normal. Our data show that NK cells in AIDS and ARC patients are in a less active state compared to those in normal.
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Baron, G. C.; Klimas, Nancy G.; Fischl, M. A.; and Fletcher, Mary A., "Decreased natural cell-mediated cytotoxicity per effector cell in acquired immunodeficiency syndrome" (1985). College of Osteopathic Medicine Faculty Articles. 451.