Faculty Articles
PubMed Identifier
2341153
Title
Localization of the rhodopsin gene to the distal half of mouse chromosome 6.
ISBN or ISSN
0888-7543
Publication Title
Genomics
Volume
6
Issue
4
Publication Date / Copyright Date
4-1990
First Page
635
Last Page
644
Publisher
Academic Press
Abstract
We have assigned the mouse rhodopsin gene, Rho, to chromosome 6 using DNA from a set of mouse-hamster somatic hybrid cell lines and a partial cDNA clone for mouse opsin. This assignment rules out the direct involvement of the rhodopsin gene in the known mouse mutations that produce retinal degeneration, including retinal degeneration slow (rds, chromosome 17), retinal degeneration (rd, chromosome 5), Purkinje cell degeneration (pcd, chromosome 13), and nervous (nr, chromosome 8). Segregation of Rho-specific DNA fragment differences among 50 animals from an interspecific backcross (C57BL/6J X Mus spretus) X C57BL/6J indicates that the Rho locus is 4.0 +/- 2.8 map units distal to the locus for the proto-oncogene Raf-1 and 18.0 +/- 5.4 map units proximal to the locus for the proto-oncogene Kras-2. Linkage to Raf-1 was confirmed using four sets of recombinant inbred strains. The two loci RAF1 and RHO are also syntenic on human chromosome 3, but on opposite arms.
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Keywords
Animals, Chromosome Inversion, Chromosome Mapping, Cricetinae, Cricetulus, Crosses, Genetic, Genetic Linkage, Humans, Hybrid Cells, Mice, Mice, Inbred Strains, Muridae, Phylogeny, Proto-Oncogenes, Recombination, Genetic, Restriction Mapping, Retinal Pigments, Rhodopsin, Species Specificity
NSUWorks Citation
Elliott, R W.; Sparkes, R S.; Mohandas, T; Grant, S G.; and McGinnis, J F., "Localization of the rhodopsin gene to the distal half of mouse chromosome 6." (1990). Faculty Articles. 1527.
https://nsuworks.nova.edu/hpd_com_faculty_articles/1527
