Faculty Articles
Title
Obesity-related kidney disease
ISBN or ISSN
0095-4543
Publication Title
Primary Care: Clinics in Office Practice
Volume
41
Issue
4
Publication Date / Copyright Date
12-1-2014
First Page
875
Last Page
893
Publisher
Elsevier
DOI Number
10.1016/j.pop.2014.08.008
Abstract
The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Keywords
Adipocytes, Age Factors, Blood Glucose, Cytokines, Dyslipidemias, Genetic Predisposition to Disease, Health Behavior, Humans, Hypertension, Inflammation, Insulin Resistance, Life Style, Obesity, Prevalence, Renal Insufficiency, Chronic, Renin-Angiotensin System, Risk Factors, Sex Factors, Sympathetic Nervous System, United States
NSUWorks Citation
Snyder, Samuel K.; Turner, G A.; and Turner, A, "Obesity-related kidney disease" (2014). Faculty Articles. 1112.
https://nsuworks.nova.edu/hpd_com_faculty_articles/1112
