College of Osteopathic Medicine Faculty Articles

Title

Obesity-related kidney disease

ISBN or ISSN

0095-4543

Publication Title

Primary Care: Clinics in Office Practice

Volume

41

Issue

4

Publication Date / Copyright Date

12-1-2014

First Page

875

Last Page

893

Publisher

Elsevier

DOI Number

10.1016/j.pop.2014.08.008

Abstract

The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

Keywords

Adipocytes, Age Factors, Blood Glucose, Cytokines, Dyslipidemias, Genetic Predisposition to Disease, Health Behavior, Humans, Hypertension, Inflammation, Insulin Resistance, Life Style, Obesity, Prevalence, Renal Insufficiency, Chronic, Renin-Angiotensin System, Risk Factors, Sex Factors, Sympathetic Nervous System, United States

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