College of Psychology: Faculty Articles

Title

Regional Cerebral Blood Flow in Schizophrenics. Tests Using the Xenon Xe 133 Inhalation Method.

Document Type

Article

Publication Date

3-1983

Keywords

Adolescent, Adult, Age Factors, Cerebrovascular Circulation, Educational Status, Functional Laterality, Middle Aged, Schizophrenia, Xenon Radioisotopes.

Publication Title

Archives of General Psychiatry

ISSN

0003-990X

Volume

40

Issue/No.

3

Abstract

Measurements of intrahemispheric and bilateral regional cerebral blood flow (CBF) for gray and white matter were compared in 29 schizophrenic patients and 22 normal controls, using the xenon Xe 133 inhalation method. Results showed significantly lower CBF values for all brain regions in the schizophrenic group, and post hoc comparisons showed relatively greater reduced gray-matter CBF values in the anterior areas of the brain. There was also a left-hemisphere frontal loss similar to that reported previously, although it was in the context of a generalized loss in anterior functioning. Interhemispheric comparison within both groups showed no differences between homologous regions for gray matter, and greater white-matter CBF values in the right hemisphere than in the left hemisphere. The findings support a hypothesis of a bilateral anterior deficit in schizophrenia.

DOI

10.1001/archpsyc.1983.01790030028003