College of Psychology: Faculty Articles

Title

Antipsychotic Medication and Social Cue Recognition in Chronic Schizophrenia

Document Type

Article

Publication Date

6-30-2010

Keywords

Analysis of Variance, Antipsychotic Agents, Chronic Disease, Cues, Memory Disorders, Neuropsychological Tests, Psychiatric Status Rating Scales, Reaction Time, Recognition, Schizophrenia, Schizophrenic Psychology, Social Behavior

Publication Title

Psychiatry Research

ISSN

0165-1781

Volume

178

Issue/No.

1

Peer Reviewed

1

Abstract

Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.

DOI

10.1016/j.psychres.2010.04.006