Intranigral Microinjection of Neurotensin Suppresses Feeding in Food Deprived Rats

Author(s)

Angela M. Waguespack, Nova Southeastern UniversityFollow
A. A. BaumeisterFollow
H. F. Hawkins
Tanya G. Anticich

Document Type

Article

Publication Date

10-1990

Publication Title

Neuropharmacology

Volume

29

Issue/Number

10

First Page

957

ISSN

0028-3908

Last Page

960

Abstract/Excerpt

This study was conducted to determine whether the substantia nigra is involved in the anorectic effect of centrally administered neurotensin. Microinjection of neurotensin (2.5–10.0 μg) into the substantia nigra produced a significant suppression of feeding in 18 hour food deprived rats. To determine if the anorectic effect resulted from a general impairment of sensory-motor functioning, eight behaviors were measured in a separate study. Significant effects were found in only two of the eight behavioral categories (sniffing and eating), and only at the highest neurotensin dose (10.0 μg). These results suggest that the substantia nigra may be involved in the anorectic effect of neurotensin.

DOI

10.1016/0028-3908(90)90147-J

NSUWorks Citation

Waguespack, A. M., Baumeister, A. A., Hawkins, H. F., Anticich, T. G. (1990). Intranigral Microinjection of Neurotensin Suppresses Feeding in Food Deprived Rats. Neuropharmacology, 29(10), 957-960.
Available at: https://nsuworks.nova.edu/cps_facarticles/502