Biology Faculty Articles

Document Type

Article

Publication Date

12-1999

Publication Title

Genome Research

ISSN

1088-9051

Volume

9

Issue/No.

12

First Page

1223

Last Page

1230

Abstract

A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY–DBY–UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.

Comments

©1999 by Cold Spring Harbor Laboratory Press

Additional Comments

GenBank accession #s: AF197956-AF197962, AF197964-AF197972

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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