Biology Faculty Articles

Document Type

Article

Publication Date

4-2004

Publication Title

Journal of Virology

ISSN

0022-538X

Volume

78

Issue/No.

8

First Page

4370

Last Page

4375

Abstract

We isolated and sequenced two complete endogenous feline leukemia viruses (enFeLVs), designated enFeLV-AGTT and enFeLV-GGAG. In enFeLV-AGTT, the open reading frames are reminiscent of a functioning FeLV genome, and the 5′ and 3′ long terminal repeat sequences are identical. Neither endogenous provirus is genetically fixed in cats but polymorphic, with 8.9 and 15.2% prevalence for enFeLV-AGTT and enFeLV-GGAG, respectively, among a survey of domestic cats. Neither provirus was found in the genomes of related species of the Felis genus, previously shown to harbor enFeLVs. The absence of mutational divergence, polymorphic incidence in cats, and absence in related species suggest that these enFeLVs may have entered the germ line more recently than previously believed, perhaps coincident with domestication, and reopens the question of whether some enFeLVs might be replication competent.

Comments

©2004 by the American Society for Microbiology

Additional Comments

National Cancer Institute contract #: N01-CO-12400; GenBank accession #s: AY364318-AY364319

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015