Biology Faculty Articles

Authors

Jacques Fellay, Duke University
Dongliang Ge, Duke University
Kevin V. Shianna, Duke University
Sara Colombo, University of Lausanne - Switzerland
Bruno Ledergerber, University of Zurich - Switzerland
Elizabeth T. Cirulli, Duke University
Thomas J. Urban, Duke University
Kunlin Zhang, University of Lausanne - Switzerland; Chinese Academy of Sciences - Beijing
Curtis Gumbs, Duke University
Jason P. Smith, Duke University
Antonella Castagna, Vita-Salute San Raffaele University and Diagnostica - Milan, Italy; Ricerca San Raffaele - Milan, Italy
Alessandro Cozzi-Lepri, University College London - United Kingdom
Andrea de Luca, Catholic University of the Sacred Heart - Rome, Italy
Philippa Easterbrook, Kings College London - United Kingdom
Huldrych F. Gunthard, University of Zurich - Switzerland
Simon Mallal, Murdoch University - Perth, Australia
Cristina Mussini, Azienda Ospedaliero-Universitaria - Modena, Italy
Judith Dalmau, IrsiCaixa Foundation; Hospital Germans Trias i Pujol - Badalona, Spain
Javier Martinez-Picado, IrsiCaixa Foundation; Hospital Germans Trias i Pujol - Badalona, Spain; Institucio Catalana de Recerca i Estudis Avancats - Barcelona, Spain
Jose M. Miro, University of Barcelona - Spain
Niels Obel, Copenhagen University - Denmark
Steven M. Wolinsky, Northwestern University
Jeremy J. Martinson, University of Pittsburgh
Roger Detels, University of California - Los Angeles
Joseph Margolick, Johns Hopkins University
Lisa Jacobson, Johns Hopkins University
Patrick Descombes, University of Geneva - Switzerland
Stylianos E. Antonarakis, University of Geneva - Switzerland
Jacques S. Beckmann, University of Lausanne - Switzerland; Centre Hospitalier Universitaire Vaudois - Lausanne, Switzerland
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Norman L. Letvin, Harvard Medical School
Andrew J. McMichael, John Radcliffe Hospital - United Kingdom
Barton F. Haynes, Duke University
Mary Carrington, National Cancer Institute at Frederick; Ragon Institute of Massachusetts General Hospital, MIT and Harvard
Sheng Feng, Duke University
Amalio Telenti, University of Lausanne - Switzerland
David B. Goldstein, Duke University
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)

Document Type

Article

Publication Date

12-2009

Publication Title

PLoS ONE

ISSN

1932-6203

Volume

5

Issue/No.

12 e1000791

First Page

1

Last Page

12

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Comments

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

Additional Comments

CHAVI grant #: AI067854; National Cancer Institute contract #: HHSN261200800001E

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015