Title

Coadaptation and Immunodeficiency Virus: Lessons from the Felidae

Authors

Margaret A. Carpenter, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

12-1995

Publication Title

Current Opinion in Genetics and Development

ISSN

0959-437X

Volume

5

Issue/No.

6

First Page

739

Last Page

745

Abstract

The emergence of pathogenic viruses in new species offers an unusual opportunity to monitor the coadaptation of viruses and their hosts in a dynamic ongoing process of intense biological selection. Tracking lentivirus epidemics in man, monkeys and cats reveals genomic struggles at three levels: quasispecies divergence within an individual; coadaptation of virus and host genomes subsequent to disease outbreaks; and transmission, spread and pathogenesis in related host species. Aspects of each level are revealed by examining the genetic diversity of feline immunodeficiency virus in domestic and wild cat species. This approach has been facilitated by the recent genetic characterization of a novel lentivirus in lions.

Comments

© 1995 Published by Elsevier Ltd.

NSUWorks Citation

Carpenter, Margaret A. and Stephen J. O'Brien. 1995. "Coadaptation and Immunodeficiency Virus: Lessons from the Felidae." Current Opinion in Genetics and Development 5, (6): 739-745. https://nsuworks.nova.edu/cnso_bio_facarticles/716

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015