Title

Influence of Combinations of Human Major Histocompatibility Complex Genes on the Course of HIV−1 Infection

Authors

Richard A. Kaslow, University of Alabama - Birmingham; National Cancer Institute at Frederick
Mary Carrington, National Cancer Institute at Frederick
R. Apple, Roche Molecular Systems, Inc.
L. Park, Johns Hopkins University
A. Muñoz, Johns Hopkins University
A. J. Saah, Johns Hopkins University
James J. Goedert, National Cancer Institute at Rockville
Cheryl Winkler, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Charles Rinaldo, University of Pittsburgh
Roger Detels, University of California, Los Angeles
W. Blattner, National Cancer Institute at Rockville
John Phair, Northwestern University Medical School
H. Erlich, Roche Molecular Systems, Inc.
Dean L. Mann, National Cancer Institute at Frederick

Document Type

Article

Publication Date

4-1996

Publication Title

Nature Medicine

ISSN

1078-8956

Volume

2

Issue/No.

4

First Page

405

Last Page

411

Abstract

Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV−1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV−1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV−1 and other infections.

Comments

©1996 Nature Publishing Group

NSUWorks Citation

Kaslow, Richard A.; Mary Carrington; R. Apple; L. Park; A. Muñoz; A. J. Saah; James J. Goedert; Cheryl Winkler; Stephen J. O'Brien; Charles Rinaldo; Roger Detels; W. Blattner; John Phair; H. Erlich; and Dean L. Mann. 1996. "Influence of Combinations of Human Major Histocompatibility Complex Genes on the Course of HIV−1 Infection." Nature Medicine 2, (4): 405-411. https://nsuworks.nova.edu/cnso_bio_facarticles/714

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015