Hypervariable Genomic Variation to Reconstruct the Natural History of Populations: Lessons from the Big Cats
DNA fingerprinting, Cheetah, Coefficient of relatedness curve, Cat microsatellites
The extent and nature of variation in hypervariable regions of DNA have been used in the past as a means to infer the natural histories of populations. We review the interpretation of the extent of genetic diversity for minisatellite DNA in the cheetah to estimate the timing of a population bottleneck in the species and the potential application of a second class of hypervariable DNA, microsatellite DNA, as a molecular tool to examine the natural histories of felid populations. A calibration curve relating the degree of allele fragment sharing in individuals to relatedness in a captive pedigree of cheetahs is presented. This measurement has important applications for management of potential matings in captive management situations.
Menotti-Raymond, Marilyn and Stephen J. O'Brien. 1995. "Hypervariable Genomic Variation to Reconstruct the Natural History of Populations: Lessons from the Big Cats." Electrophoresis 16, (1): 1771-1774. http://nsuworks.nova.edu/cnso_bio_facarticles/713