Title

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

Authors

Cheryl Winkler, National Cancer Institute at Frederick
William Modi, National Cancer Institute at Frederick
Michael W. Smith, National Cancer Institute at Frederick
George W. Nelson, National Cancer Institute at Frederick
Xueyun Wu, National Cancer Institute at Frederick
Mary Carrington, National Cancer Institute at Frederick
Michael Dean, National Cancer Institute at Frederick
Tasaku Honjo, Kyoto University
Kai Tashiro, Kyoto University
D. Yabe, Kyoto University
Susan Buchbinder, San Francisco Department of Public Health
Eric Vittinghoff, San Francisco Department of Public Health
James J. Goedert, National Cancer Institute at Bethesda
Thomas R. O'Brien, National Cancer Institute at Bethesda
Lisa Jacobson, Johns Hopkins School of Hygiene and Public Health
Roger Detels, University of California - Los Angeles
Sharyne Donfield, Rho, Inc.
Anne Willoughby, National Institute of Child Health and Human Development
Edward Gomperts, Children's Hospital of Los Angeles
David Vlahov, Johns Hopkins School of Hygiene and Public Health
John Phair, Northwestern University Medical School
ALIVE Study
Hemophilia Growth and Development Study
Multicenter AIDS Cohort Study
Multicenter Hemophilia Cohort Study
San Francisco City Cohort
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1-16-1998

Publication Title

Science

ISSN

0036-8075

Volume

279

Issue/No.

5349

First Page

389

Last Page

393

Abstract

Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic human immunodeficiency virus-type 1 (HIV-1). A common polymorphism, SDF1-3′A, was identified in an evolutionarily conserved segment of the 3′ untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3′A/3′A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3′A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.

Comments

©1998 American Association for the Advancement of Science

NSUWorks Citation

Winkler, Cheryl; William Modi; Michael W. Smith; George W. Nelson; Xueyun Wu; Mary Carrington; Michael Dean; Tasaku Honjo; Kai Tashiro; D. Yabe; Susan Buchbinder; Eric Vittinghoff; James J. Goedert; Thomas R. O'Brien; Lisa Jacobson; Roger Detels; Sharyne Donfield; Anne Willoughby; Edward Gomperts; David Vlahov; John Phair; ALIVE Study; Hemophilia Growth and Development Study; Multicenter AIDS Cohort Study; Multicenter Hemophilia Cohort Study; San Francisco City Cohort; and Stephen J. O'Brien. 1998. "Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant." Science 279, (5349): 389-393. https://nsuworks.nova.edu/cnso_bio_facarticles/674

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015