Biology Faculty Articles

Title

Distribution of Two HIV-1–Resistant Polymorphisms (SDF1-30A and CCR2-64I) in East Asian and World Populations and Its Implication in AIDS Epidemiology

Document Type

Article

Publication Date

10-1999

Publication Title

American Journal of Human Genetics

ISSN

0002-9297

Volume

65

Issue/No.

1

First Page

1047

Last Page

1053

Abstract

Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3′A, can delay AIDS onset ⩾16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3′A is recessive. SDF1-3′A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1–0.2 in most populations. A decreasing cline of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3′A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing cline of the SDF1-3′A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations.

Comments

©1999 by The American Society of Human Genetics

Additional Comments

National Institute of Health grant #s: R01GM41399, RO1GM55759

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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