Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-Δ32 Mutation
Non-Hodgkin’s lymphoma (NHL) has been increasing in frequency in the industrialized world, but the environmental and genetic factors that contribute to susceptibility are not known. B-cell lymphomas represent a major cause of morbidity and mortality in HIV-infected individuals. The identification of a deletion in the CCR5 chemokine receptor gene that alters the risk for infection and progression to AIDS led us to examine a potential role of this gene in AIDS lymphoma. A matched case-control analysis was performed using all eligible NHL cases in the Multicenter AIDS Cohort Study. Patients were matched for age, study center, time AIDS-free, and slope of the CD4+ T-cell decline. The CCR5-D32 allele was found to be associated with a 3-fold lower risk of NHL among individuals after controlling for time of infection and progression toward AIDS. The CCR5 gene was not associated with a difference in risk for Kaposi’s sarcoma, another common malignancy in AIDS patients, or opportunistic infections. Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells. Taken together, these findings suggest that the CCR5 gene plays a role in the risk of NHL in HIV-infected patients, perhaps through a mechanism involving a decreased response of B cells to the mitogenic activity of RANTES.
Dean, Michael; Lisa Jacobson; Glen McFarlane; Joseph Margolick; Frank J. Jenkins; O. M. Zack Howard; Hui-Fang Dong; James J. Goedert; Susan Buchbinder; Edward Gomperts; David Vlahov; Joost J. Oppenheim; Stephen J. O'Brien; and Mary Carrington. 1999. "Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-Δ32 Mutation." Cancer Research 59, (15): 3561-3564. http://nsuworks.nova.edu/cnso_bio_facarticles/652