Biology Faculty Articles

Title

Hepatitis C Virus Load is Associated with Human Immunodeficiency Virus Type 1 Disease Progression in Hemophiliacs

Document Type

Article

Publication Date

2-15-2001

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

183

Issue/No.

4

First Page

589

Last Page

595

Abstract

Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV-coinfected patients. Patients were followed prospectively for ∼7 years, and annual measurements of CD4⁺ cell counts and HCV and HIV-1 loads were obtained. Survival analysis was used to define the independent effects of HCV load on HIV-1 progression. After controlling for CD4⁺ cell count and HIV1 RNA level, every 10-fold increase in baseline HCV RNA was associated with a relative risk (RR) for clinical progression to acquired immunodeficiency syndrome (AIDS) of 1.66 (95% confidence interval [CI], 1.10-2.51; P = .016) and an RR for AIDS-related mortality of 1.54 (95% CI, 1.03-2.30; P = .036). These findings emphasize the need for further research regarding the use of HIV-1- and HCV-specific therapy in coinfected individuals.

Comments

©2001 by the Infectious Diseases Society of America

Additional Comments

National Institutes of Health grant #s: MO1-RR06020, MO1-RR00071, MO1-RR00059, MO1-RR02558; Bureau of Maternal and Child Health and Resources Development grant #: MCJ-060570; National Institute of Child Health and Human Development grant #: NO1-HD-4-3200; National Cancer Institute grant #: NO1-CO-56000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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