Title

Integration of the Feline Radiation Hybrid and Linkage Maps

Authors

Shan Sun, National Cancer Institute at Frederick; George Mason University
William J. Murphy, National Cancer Institute at Frederick
Marilyn Menotti-Raymond, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

6-2001

Publication Title

Mammalian Genome

ISSN

0938-8990

Volume

12

Issue/No.

6

First Page

436

Last Page

441

Abstract

The recent development of genome mapping resources for the domestic cat provides a unique opportunity to study comparative medicine in this companion animal which can inform and benefit both veterinary and human biomedical concerns. We describe here the integration and order comparison of the feline radiation hybrid (RH) map with the feline interspecies backcross (ISB) genetic linkage map, constructed by a backcross of F1 hybrids between domestic cat (Felis catus) and the Asian leopard cat (Prionailurus bengalensis). Of 253 microsatellite loci mapped in the ISB, 176 equivalently spaced markers were ordered among a framework of 424 Type I coding markers in the RH map. The integration of the RH and ISB maps resolves the orientation of multiple linkage groups and singleton loci from the ISB genetic map. This integrated map provides the foundation for gene mapping assessments in the domestic cat and in related species of the Felidae family.

Comments

©Springer-Verlag New York Inc. 2001

NSUWorks Citation

Sun, Shan; William J. Murphy; Marilyn Menotti-Raymond; and Stephen J. O'Brien. 2001. "Integration of the Feline Radiation Hybrid and Linkage Maps." Mammalian Genome 12, (6): 436-441. https://nsuworks.nova.edu/cnso_bio_facarticles/632

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015