Title

The Effect of Genetic Variation in Chemokines and Their Receptors on HIV Transmission and Progression to AIDS

Authors

Stephen J. O'Brien, National Cancer Institute at FrederickFollow
John P. Moore, Cornell University

Document Type

Article

Publication Date

10-2000

Publication Title

Immunological Reviews

Keywords

Chemokines, Genetics, AIDS

ISSN

0105-2896

Volume

177

Issue/No.

1

First Page

99

Last Page

111

Abstract

The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry stimulated a search for common genetic polymorphism in their genes which might affect the course of AIDS. Four mutational variants, CCR5-Δ32, CCR5P1, CCR2-641 and SDF1-3'A were discovered to play a regulatory role in HIV-1 infection, in the rate of progression to AIDS or both. Plausible physiological mechanisms to explain the population genetic association by these alleles have been advanced and are discussed critically here. Genetic ablation of AIDS progression by chemokine receptor and ligand gene variants has catalyzed development of novel therapies targeting the virus-co-receptor interaction. The functional and therapeutic implications of these AIDS restriction genes for disease progression and intervention are explored in this review.

Comments

©Munksgaard 2000

NSUWorks Citation

O'Brien, Stephen J. and John P. Moore. 2000. "The Effect of Genetic Variation in Chemokines and Their Receptors on HIV Transmission and Progression to AIDS." Immunological Reviews 177, (1): 99-111. https://nsuworks.nova.edu/cnso_bio_facarticles/629

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015