A Tumor Necrosis Factor-α-Inducible Promoter Variant of Interferon-γ Accelerates CD4+ T Cell Depletion in Human Immunodeficiency Virus-1-Infected Individuals
Journal of Infectious Diseases
A polymorphism,—179G/T, in the promoter of the interferon (IFN)-γ gene (IFNG) confers differential tumor necrosis factor-α (TNF-α) inducibility to the IFNG =romoter. The rarer allele, −179T, but not −179G, is inducible by TNF-α.We investigated the effects of IFNG −179G/T on AIDS pathogenesis. In 298 African American human immunodeficiency virus (HIV)-1 seroconverters, the IFNG −179G/T genotype was associated with accelerated progression to CD4<200 and AIDS-1993, a finding suggesting that IFNG −179T is a risk factor for AIDS progression, as measured by CD4 cell count. It is possible that increased IFN-γ production induced by TNF-α when −179T is present causes CD4 cell depletion by apoptosis.
An, Ping; David Vlahov; Joseph Margolick; John Phair; Thomas R. O'Brien; J. A. Lautenberger; Stephen J. O'Brien; and Cheryl Winkler. 2003. "A Tumor Necrosis Factor-α-Inducible Promoter Variant of Interferon-γ Accelerates CD4+ T Cell Depletion in Human Immunodeficiency Virus-1-Infected Individuals." Journal of Infectious Diseases 188, (2): 228-231. http://nsuworks.nova.edu/cnso_bio_facarticles/609