Biology Faculty Articles

Title

Association of Polymorphisms in Human Leukocyte Antigen Class I and Transporter Associated with Antigen Processing Genes with Resistance to Human Immunodeficiency Virus Type 1 Infection

Document Type

Article

Publication Date

5-1-2003

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

187

Issue/No.

9

First Page

1404

Last Page

1410

Abstract

To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33–4.84; P = .009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08–0.99; P = .037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35–3.79; P = .002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8+ T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34–23.10; P = .018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28–3.84; P = .005) were associated with resistance.

Comments

©2003 by the Infectious Diseases Society of America

Additional Comments

National Cancer Institute grant #s: UO1-AI-35042, UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041; NIAID grant #: 5-MO1-RR-00722; National Institutes of Health contract #: NO1-CO-12400

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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