Biology Faculty Articles

Title

HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

Document Type

Article

Publication Date

8-6-2004

Publication Title

Science

ISSN

0036-8075

Volume

305

Issue/No.

5685

First Page

872

Last Page

874

Abstract

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

Comments

©2004 American Association for the Advancement of Science

Additional Comments

National Cancer Institute contract #s: NO1-CO-12400, N01-CP-33002, N01-CP-01004; NIH grant #s: DA00441, DA04334, DA13324; Bureau of Maternal and Child Health and Resources Development grant #: MCJ-060570; National Institute of Child Health and Human Development grant #: NO1-HD-4-3200

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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