Title

Single Nucleotide Polymorphisms and Haplotypes in the IL10 Region Associated with HCV Clearance

Authors

T. K. Oleksyk, National Cancer Institute at Frederick
Chloe L. Thio, Johns Hopkins University
Ann L. Truelove, National Cancer Institute at Frederick
James J. Goedert, National Cancer Institute at Bethesda
Sharyne Donfield, Rho, Inc.
Gregory D. Kirk, Johns Hopkins University
D. L. Thomas, Johns Hopkins University
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
M. W. Smith, National Cancer Institute at Frederick

Document Type

Article

Publication Date

6-2005

Publication Title

Genes and Immunity

Keywords

Hepatitis C clearance, IL10 region, IL19, IL20, Haplotypes, Genetic association

ISSN

1466-4879

Volume

6

Issue/No.

4

First Page

347

Last Page

357

Abstract

Hepatitis C virus (HCV) is an infectious blood-borne pathogen that usually persists as a chronic infection. However, approximately 15% of the time, patients can clear the virus, indicating that host differences could be critical in determining the course of HCV infection. The inflammatory response is crucial to resolving or failing to resolve an acute HCV infection. Some previous reports have implicated interleukin 10 (IL10) polymorphisms with successful anti-HCV therapy and natural viral clearance. We tested 54 single nucleotide polymorphisms (SNPs) in the IL10 region (+/-300 kb and 24 within the IL10 gene itself), which contains 13 genes including the IL10 immunomodulatory paralogs IL19, IL20, and IL24, for association with HCV clearance vs persistence. SNPs from two haplotype block regions, one at IL10 and the other from IL19/IL20, were associated with HCV clearance in African Americans (91 clearance cases and 183 chronically infected matched controls; P=0.05-0.002) while with expectation-maximization algorithm-reconstructed haplotypes, these associations remained (P=0.05-0.002). However, no significant associations were detected in European Americans (108 clearance and 245 chronic). Our results indicate that variants of the immunomodulatory IL10 and IL19/IL20 genes may be involved in natural clearance of HCV in the African-American population.

Comments

©2005 Nature Publishing Group

Additional Comments

National Cancer Institute contract #: NO1-CO-12400; NIH grant #s: DA13324, DA00441

NSUWorks Citation

Oleksyk, T. K.; Chloe L. Thio; Ann L. Truelove; James J. Goedert; Sharyne Donfield; Gregory D. Kirk; D. L. Thomas; Stephen J. O'Brien; and M. W. Smith. 2005. "Single Nucleotide Polymorphisms and Haplotypes in the IL10 Region Associated with HCV Clearance." Genes and Immunity 6, (4): 347-357. https://nsuworks.nova.edu/cnso_bio_facarticles/542

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015