Biology Faculty Articles

Title

Mapping by Admixture Linkage Disequilibrium: Advances, Limitations and Guidelines

Document Type

Article

Publication Date

8-2005

Publication Title

Nature Reviews Genetics

ISSN

1471-0056

Volume

6

Issue/No.

8

First Page

623

Last Page

632

Abstract

Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.

Comments

©2005 Nature Publishing Group

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

This document is currently not available here.

Find in your library

Share

COinS