Mapping by Admixture Linkage Disequilibrium: Advances, Limitations and Guidelines
Nature Reviews Genetics
Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.
Smith, Michael W. and Stephen J. O'Brien. 2005. "Mapping by Admixture Linkage Disequilibrium: Advances, Limitations and Guidelines." Nature Reviews Genetics 6, (8): 623-632. http://nsuworks.nova.edu/cnso_bio_facarticles/533