Biology Faculty Articles

Title

Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps

Document Type

Article

Publication Date

7-22-2005

Publication Title

Science

ISSN

0036-8075

Volume

309

Issue/No.

5734

First Page

613

Last Page

617

Abstract

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

Comments

©2005 American Association for the Advancement of Science

Additional Comments

NIH grant #: R01CA-92167; USDA National Research Initiative grant #: AG2004-3520-14196; USDA Cooperative State Research, Education and Extension Service grant #: AG2004-34480-14417; National Cancer Institute contract #: N01-CO-12400

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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