Biology Faculty Articles

Title

Searching for Signals of Evolutionary Selection in 168 Genes Related to Immune Function

Document Type

Article

Publication Date

3-2006

Publication Title

Human Genetics

Keywords

Metabolic diseases, Gene function, Molecular medicine, Human genetics

ISSN

0340-6717

Volume

119

Issue/No.

1-2

First Page

92

Last Page

102

Abstract

Pathogens have played a substantial role in human evolution, with past infections shaping genetic variation at loci influencing immune function. We selected 168 genes known to be involved in the immune response, genotyped common single nucleotide polymorphisms across each gene in three population samples (CEPH Europeans from Utah, Han Chinese from Guangxi, and Yoruba Nigerians from Southwest Nigeria) and searched for evidence of selection based on four tests for non-neutral evolution: minor allele frequency (MAF), derived allele frequency (DAF), Fst versus heterozygosity and extended haplotype homozygosity (EHH). Six of the 168 genes show some evidence for non-neutral evolution in this initial screen, with two showing similar signals in independent data from the International HapMap Project. These analyses identify two loci involved in immune function that are candidates for having been subject to evolutionary selection, and highlight a number of analytical challenges in searching for selection in genome-wide polymorphism data.

Comments

©Springer-Verlag 2005

Additional Comments

National Cancer Institute contracat #: NO1-CO-12400

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

This document is currently not available here.

Find in your library

Share

COinS