Biology Faculty Articles

Title

Innate Partnership of HLA-B and KIR3DL1 Subtypes Against HIV-1

Document Type

Article

Publication Date

6-2007

Publication Title

Nature Genetics

ISSN

1061-4036

Volume

39

Issue/No.

6

First Page

733

Last Page

740

Abstract

Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns and inhibitory capacity upon binding to their ligands, HLA-B Bw4 molecules, present on target cells. Using a sample size of over 1,500 human immunodeficiency virus (HIV)+ individuals, we show that various distinct allelic combinations of the KIR3DL1 and HLA-B loci significantly and strongly influence both AIDS progression and plasma HIV RNA abundance in a consistent manner. These genetic data correlate very well with previously defined functional differences that distinguish KIR3DL1 allotypes. The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.

Comments

©2007 Nature Publishing Group

Additional Comments

National Cancer Institute contract #: N01-CO-12400; US National Institute on Drug Abuse grant #: RO1-DA04334; NIH grant #: P30 AI027763

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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