Biology Faculty Articles

Title

Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

Document Type

Article

Publication Date

9-2007

Publication Title

Journal of Heredity

ISSN

0022-1503

Volume

98

Issue/No.

6

First Page

555

Last Page

566

Abstract

To determine the genetic regulation of “hair length” in the domestic cat, a whole-genome scan was performed in a multigenerational pedigree in which the “long-haired” phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds ≥ 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candidate gene implicated in regulating hair follicle growth cycle in other species. Sequence analyses of FGF5 in 26 cat breeds and 2 pedigrees of nonbreed cats revealed 4 separate mutations predicted to disrupt the biological activity of the FGF5 protein. Pedigree analyses demonstrated that different combinations of paired mutant FGF5 alleles segregated with the long-haired phenotype in an autosomal recessive manner. Association analyses of more than 380 genotyped breed and nonbreed cats were consistent with mutations in the FGF5 gene causing the long-haired phenotype in an autosomal recessive manner. In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat.

Comments

©The American Genetic Association. 2007. All rights reserved.

Additional Comments

National Institutes of Health grant #: RR019677-01; National Institutes on Deafness and Other Communication Disorders grant #: DC00232

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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