Biology Faculty Articles

Title

Mitochondrial DNA Haplogroups Influence AIDS Progression

Document Type

Article

Publication Date

11-30-2008

Publication Title

AIDS

Keywords

AIDS, Apoptosis, Disease, HIV-1, Mitochondria

ISSN

0269-9370

Volume

22

Issue/No.

18

First Page

2429

Last Page

2439

Abstract

Objective: Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA singlenucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis.

Design: This is a retrospective cohort study. Methods: We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to determine whether the mitochondrial DNA haplogroup correlated with AIDS progression rate.

Results: Mitochondrial DNA haplogroups J and U5a were elevated among HIV-1 infected people who display accelerated progression to AIDS and death. Haplogroups Uk, H3, and IWX appeared to be highly protective against AIDS progression.

Conclusion: The associations found in our study appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative. These data suggest that mitochondrial genes are important indicators of AIDS disease progression in HIV-1 infected persons.

Comments

©2008 Wolters Kluwer Health

Additional Comments

National Cancer Institute contract #s: N01-CO-12400, UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, N02- CP-55504; Spanish Fondo de Investigacion Sanitaria grant #: FIS-PI05-0647; NIH grant #s: R01 AG24373, DK7369

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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