Evaluation of Nonviral Risk Factors for Nasopharyngeal Carcinoma in a High-Risk Population of Southern China
International Journal of Cancer
Nasopharyngeal carcinoma, Risk factor, Epidemiology, Southern China, Epstein Barr virus
To understand the role of environmental and genetic influences on nasopharyngeal carcinoma (NPC) in populations at high risk of NPC, we have performed a case-control study in Guangxi Province of Southern China in 2004–2005. NPC cases (n = 1,049) were compared with 785 NPC-free matched controls who were seropositive for IgA antibodies (IgA) to Epstein-Barr virus (EBV) capsid antigen (VCA)—a predictive marker for NPC in Chinese populations. A questionnaire was used to capture exposure and NPC family history data. Risk factors associated with NPC in a multivariant analysis model were the following: (i) a first, second or third degree relative with NPC [attributable risk (AR)= 6%, odds ratio (OR) = 3.1, 95% confidence interval (CI) = 2.0–4.9, p < 0.001]; (ii) consumption of salted fish 3 or more than 3 times per month (AR = 3%, OR = 1.9, 95% CI = 1.1–3.5, p = 0.035); (iii) exposure to domestic wood cooking fires for more than 10 years (AR = 69%, OR = 5.8, 95% CI = 2.5–13.6, p < 0.001); and (iv) exposure to occupational solvents for 10 or less years (AR = 4%, OR = 2.6, 95% CI = 1.4–4.8, p = 0.002). Consumption of preserved meats or a history of tobacco smoking were not associated with NPC (p > 0.05). We also assessed the contribution of EBV/IgA/VCA antibody serostatus to NPC risk—32.2% of NPC can be explained by IgA+ status. However, family history and environmental risk factors cumulatively explained only 2.7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions.
Guo, Xiuchan; Randall C. Johnson; Hong Deng; Jian Liao; Li Guan; George W. Nelson; Mingzhong Tang; Yuming Zheng; Guy de The; Stephen J. O'Brien; Cheryl Winkler; and Yi Zeng. 2009. "Evaluation of Nonviral Risk Factors for Nasopharyngeal Carcinoma in a High-Risk Population of Southern China." International Journal of Cancer 124, (12): 2942-2947. http://nsuworks.nova.edu/cnso_bio_facarticles/471