Biology Faculty Articles

Title

Haplotype-Dependent HLA Susceptibility to Nasopharyngeal Carcinoma in a Southern Chinese Population

Document Type

Article

Publication Date

6-2010

Publication Title

Genes and Immunity

Keywords

HLA, Nasopharyngeal carcinoma, Haplotype, Stratified analysis

ISSN

1466-4879

Volume

11

Issue/No.

4

First Page

334

Last Page

342

Abstract

We have conducted a comprehensive case–control study of a nasopharyngeal carcinoma (NPC) population cohort from Guangxi Province of Southern China, a region with one of the highest NPC incidences on record. A total of 1407 individuals including NPC patients, healthy controls, and their adult children were examined for the human leukocyte antigen (HLA) association, which is so far the largest NPC cohort reported for such studies. Stratified analysis performed in this study clearly demonstrated that while NPC protection is associated with independent HLA alleles, most NPC susceptibility is strictly associated with HLA haplotypes. Our study also detected for the first time that A*0206, a unique A2 subtype to South and Southeast Asia is also associated with a high risk for NPC. HLA-A*0206, HLA-B*3802 alleles plus the A*0207–B*4601 and A*3303–B*5801 haplotypes conferred high risk for NPC showing a combined odds ratio (OR) of 2.6 (P<0.0001). HLA alleles that associate with low risk for NPC include HLA-A*1101, B*27, and B*55 with a combined OR of 0.42 (P<0.0001). The overall high frequency of NPC-susceptible HLA factors in the Guangxi population is likely to have contributed to the high-NPC incidence in this region.

Comments

©2010 Macmillan Publishers Limited All rights reserved

Additional Comments

National Cancer Institute contract #: HHSN261200800001E

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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