Biology Faculty Articles

Title

Effect of Host Genetics on Incidence of HIV Neuroretinal Disorder in Patients with AIDS

Document Type

Article

Publication Date

8-1-2010

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Keywords

AIDS, HIV-1, Host genetics, HIV-neuroretinal disorder

ISSN

1525-4135

Volume

54

Issue/No.

4

First Page

343

Last Page

351

Abstract

Approximately 10%-15% of patients with AIDS but without ocular opportunistic infections will have a presumed neuroretinal disorder (HIV-NRD), manifested by reduced contrast sensitivity and abnormal visual fields. The loss of contrast sensitivity often is sufficient to impair reading speed. To evaluate the effect of host genetics on HIV-NRD, we explored validated AIDS restriction gene variants CCR5Δ32, CCR2-64I, CCR5 P1, SDF-3'A, IL-10-5'A, RANTES -403A, RANTES -28G, RANTES-In1.1C, CX3CR1-249I, CX3CR1-280M, IFNG-179T, MDR1-3435T, and MCP-1364G, each of which has been implicated previously to influence HIV-1 infection, AIDS progression, therapy response, and antiviral drug metabolism, and an IL-10 receptor gene, IL-10R1, in the Longitudinal Study of the Ocular Complications of AIDS cohort. In European Americans (cases = 55, controls = 290), IL-10-5'A variant and its promoter haplotype (hazard ratio = 2.09, confidence interval. 1.19 to 3.67, P = 0.01), in African Americans (cases = 54, controls = 180), RANTES-In1.1C and the associated haplotype (hazard ratio = 2.72, confidence interval.: 1.48 to 5.00, P = 0.001), showed increased HIV-NRD susceptibility. Although sample sizes are small and P values do not pass a strict Bonferroni correction, our results suggest that, in European Americans, an IL-10-related pathway, and, in African Americans, chemokine receptor ligand polymorphisms in RANTES are risk factors for HIV-NRD development. Clearly, further studies are warrented.

Comments

©2010 by Lippincott Williams & Wilkins

Additional Comments

National Cancer Institute contract #s: N01-CO-12400, HHSN26120080001E; National Eye Institute agreement #s: U10-EY-08052, U10-EY-08057, U10-EY-08067

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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