Title

A Common HLA–DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

Authors

Ping An, National Cancer Institute at Frederick
Cheryl Winkler, National Cancer Institute at Frederick
Li Guan, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Zheng Zeng, Peking University - China
HBV Study Consortium

Document Type

Article

Publication Date

4-1-2011

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

203

Issue/No.

7

First Page

943

Last Page

947

Abstract

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n= 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

Comments

©The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

Additional Comments

National Cancer Institute contract #: HHSN26120080001E

NSUWorks Citation

An, Ping; Cheryl Winkler; Li Guan; Stephen J. O'Brien; Zheng Zeng; and HBV Study Consortium. 2011. "A Common HLA–DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese." Journal of Infectious Diseases 203, (7): 943-947. https://nsuworks.nova.edu/cnso_bio_facarticles/449

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015