Title

Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection

Authors

Leslie Chinn, National Cancer Institute at Frederick
M. Tang, National Cancer Institute at Frederick
Bailey Kessing, National Cancer Institute at Frederick
J. A. Lautenberger, National Cancer Institute at Frederick
Jennifer L. Troyer, National Cancer Institute at Frederick
Michael Malasky, National Cancer Institute at Frederick
Carl McIntosh, National Cancer Institute at Frederick
Gregory D. Kirk, Johns Hopkins University
Steven M. Wolinsky, Northwestern University
Susan Buchbinder, San Francisco Department of Public Health
Edward Gomperts, Children's Hospital of Los Angeles
James J. Goedert, National Cancer Institute at Rockville
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

12-15-2010

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

202

Issue/No.

12

First Page

1836

Last Page

1845

Abstract

Background. High-throughput genome-wide techniques have facilitated the identification of previously unknown host proteins involved in cellular human immunodeficiency virus (HIV) infection. Recently, 3 independent studies have used small interfering RNA technology to silence each gene in the human genome to determine the importance of each in HIV infection. Genes conferring a significant effect were termed HIV-dependency factors (HDFs).

Methods. We assembled high-density panels of 6380 single-nucleotide polymorphisms (SNPs) in 278 HDF genes and tested for genotype associations with HIV infection and AIDS progression in 1633 individuals from clinical AIDS cohorts.

Results. After statistical correction for multiple tests, significant associations with HIV acquisition were found for SNPs in 2 genes, NCOR2 and IDH1. Weaker associations with AIDS progression were revealed for SNPs within the TM9SF2 and EGFR genes.

Conclusions. This study independently verifies the influence of NCOR2 and IDH1 on HIV transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.

Comments

©2010 by the Infectious Diseases Society of America. All rights reserved.

Additional Comments

National Cancer Institute contract #s: HHSN261200800001E, N02-CP-55504, UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, N01-CO-12400; NIH grant #s: R01-DA-04334, R01-DA-12568, UO1-AI-35042, 5-MO1-RR-00722, UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, M01 RR00425; National Institute of Child Health and Human Development grant #: 1 R01 HD41224

NSUWorks Citation

Chinn, Leslie; M. Tang; Bailey Kessing; J. A. Lautenberger; Jennifer L. Troyer; Michael Malasky; Carl McIntosh; Gregory D. Kirk; Steven M. Wolinsky; Susan Buchbinder; Edward Gomperts; James J. Goedert; and Stephen J. O'Brien. 2010. "Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection." Journal of Infectious Diseases 202, (12): 1836-1845. https://nsuworks.nova.edu/cnso_bio_facarticles/445

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015