Biology Faculty Articles

Title

Association of Host Genetic Risk Factors with the Course of Cytomegalovirus Retinitis in Patients Infected with Human Immunodeficiency Virus

Document Type

Article

Publication Date

6-2011

Publication Title

American Journal of Ophthalmology

ISSN

0002-9394

Volume

151

Issue/No.

6

First Page

996

Last Page

10006.e4

Abstract

PURPOSE: To evaluate the effects of previously reported host genetics factors that influence cytomegalovirus (CMV) retinitis incidence, progression to acquired immune deficiency syndrome (AIDS), and efficacy of highly active antiretroviral therapy (HAART) for mortality, retinitis progression, and retinal detachment in patients with CMV retinitis and AIDS in the era of HAART.

DESIGN: Prospective, multicenter, observational study.

METHODS: Cox proportional hazards model based genetic association tests examined the influence of IL-10R1_S420L, CCR5-Δ32, CCR2-V64I, CCR5 promoter, and SDF-3′A polymorphisms among patients with mortality, retinitis progression, and retinal detachment. Participants were 203 European-American and 117 African-American patients with AIDS and CMV retinitis.

RESULTS: European-American patients with the CCR5 +.P1.+ promoter haplotype showed increased risk for mortality (hazard ratio [HR] = 1.83; 95% confidence interval [CI]: 1.00-3.40; P = .05). Although the same haplotype also trended for increased risk for mortality in African-American patients, the result was not significant (HR = 2.28; 95% CI: 0.93-5.60; P = .07). However, this haplotype was associated with faster retinitis progression in African Americans (HR = 5.22; 95% CI: 1.54-17.71; P = .007). Increased risk of retinitis progression was also evident for African-American patients with the SDF1-3′A variant (HR = 3.89; 95% CI: 1.42-10.60; P = .008). In addition, the SDF1-3′A variant increased the retinal detachment risk in this patient group (HR = 3.05; 95% CI: 1.01-9.16; P = .05).

CONCLUSION: Besides overall immune health, host genetic factors influence mortality, retinitis progression, and retinal detachment in patients with AIDS and CMV retinitis that are receiving HAART.

Comments

Published by Elsevier Inc.

Additional Comments

National Eye Institute agreements: U10 EY 08052, U10 EY 08057, U10 EY 08067; General Clinical Research Center grant #s: 5M01 RR 00350, 5M01 RR 05096, 5M01 RR00096, 5M01 RR00865, 5M01 RR00046, 5M01 RR00043, ULI RR024996, U01 AI 27674, U01 AI 27660, U01 AI 27670, U01 AI 27663, U01 AI25868, U01 AI32783

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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