Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF/IL-8) Resides in a Gene Cluster along with Several Other Members of the Platelet Factor 4 Gene Superfamily
Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.
Modi, William; Michael Dean; Hector Seuanez; Naofumi Mukaida; Kouji Matsushima; and Stephen J. O'Brien. 1990. "Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF/IL-8) Resides in a Gene Cluster along with Several Other Members of the Platelet Factor 4 Gene Superfamily." Human Genetics 84, (2): 185-187. http://nsuworks.nova.edu/cnso_bio_facarticles/339