Biology Faculty Articles

Title

Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF/IL-8) Resides in a Gene Cluster along with Several Other Members of the Platelet Factor 4 Gene Superfamily

Document Type

Article

Publication Date

1-1990

Publication Title

Human Genetics

ISSN

0340-6717

Volume

84

Issue/No.

2

First Page

185

Last Page

187

Abstract

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.

Comments

©1990 Springer-Verlag

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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