Biology Faculty Articles

Title

Molecular Cloning, Chromosomal Assignment, and Nucleotide Sequence of the Feline Homeobox HOX3A

Document Type

Article

Publication Date

12-1991

Publication Title

Genomics

ISSN

0888-7543

Volume

11

Issue/No.

4

First Page

1007

Last Page

1013

Abstract

The feline homolog to the mammalian homeobox locus, HOX3A, was isolated by screening a domestic cat genomic library with the murine Hox-3.1 probe. The nucleotide sequence similarity of the feline homeobox was 96% to human HOX3A, 94% to mouseHox-3.1, and 94% to rat R4. The deduced amino acid sequence (homeodomain) of this feline homeobox was identical to all homeodomains of these cognate genes. Using a panel of feline × rodent somatic cell hybrids, the HOX3A locus was assigned to feline chromosome B4. Human HOX3A and mouse Hox-3.1 have been mapped previously to human chromosome 12 and mouse chromosome 15, respectively, both of which share syntenic homology to feline chromosome B4. These data demonstrate evolutionary conservation of both HOX3A gene sequences and chromosomal location during mammalian evolution.

Comments

© 1991 Published by Elsevier Inc.

Additional Comments

GenBank accession #: M62698

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

This document is currently not available here.

Find in your library

Share

COinS