Biology Faculty Articles

Title

The Human Chromogranin A Gene: Chromosome Assignment and RFLP Analysis.

Document Type

Article

Publication Date

11-1989

Publication Title

American Journal of Human Genetics

ISSN

0002-9297

Volume

45

Issue/No.

5

First Page

814

Last Page

818

Abstract

Chromogranin A/secretory protein I (CgA) is a glycoprotein that is stored and released along with peptide hormones and neurotransmitters from several tissues, although its exact function is not known. A cDNA (gene symbol CHGA) clone was used as a probe in Southern blot analyses of human-rodent somatic cell hybrid DNAs. Discordancy analysis allowed confirmation of the assignment of the gene to chromosome 14. These results were extended using in situ chromosome hybridization, and a signal was found at 14q32. BglII digestion of genomic DNA from 28 unrelated Caucasian individuals probed with CHGA detected a two-allele RFLP with allelic frequencies of .34 and .66.

Comments

This material is in the public domain, and no copyright is claimed.

Additional Comments

NIH grant #: Dk-38990; Health and Human Services contract #: NO1-CO-74102

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015