Biology Faculty Articles

Title

Sequence and Chromosomal Location of the I-309 Gene. Relationship to Genes Encoding a Family of Inflammatory Cytokines

Document Type

Article

Publication Date

10-15-1990

Publication Title

Journal of Immunology

ISSN

0022-1767

Volume

145

Issue/No.

8

First Page

2737

Last Page

2744

Abstract

We previously reported the isolation and characterization of a cDNA clone, I-309, that encodes a small secreted protein produced by activated human T lymphocytes. This protein is structurally related to a large number of recently identified proteins that are secreted upon cellular activation. In this report we describe the isolation and characterization of the gene encoding I-309. The genomic organization is essentially identical to that found in the genes encoding the structurally similar proteins TCA-3, hJE/MCP-1, and mJE, strengthening the hypothesis that these genes are evolutionarily related. The region of the I-309 gene 5' of the mRNA cap site exhibits extensive nucleotide sequence homology with the same region of the murine gene TCA-3, providing additional evidence that I-309 and TCA-3 are likely to be homologs. Finally, panels of rodent-human somatic cell hybrids were used to map the I-309 gene to human chromosome 17. In conjunction with recent mapping data from other laboratories, this result suggests the presence of a cluster of related genes on this chromosome.

Comments

©1990 by American Association of Immunologists

Additional Comments

NSF grant #: DCB-8617540

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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