Biology Faculty Articles

Title

Polymorphisms in the 3′ Untranslated Region of the IκB/MAD-3 (NFKBI) Gene Located on Chromosome 14

Document Type

Article

Publication Date

6-1994

Publication Title

Human Genetics

ISSN

0340-6717

Volume

93

Issue/No.

6

First Page

694

Last Page

696

Abstract

The NF-κB transcription factor regulates the expression of a number of genes, including immune function and growth control loci, and several viruses. For example, the long terminal repeat of the human immunodeficiency virus contains NF-κB binding sites. NF-κB activity in the nucleus is regulated by a cellular inhibitory protein IκB. To analyze the potential role of these genes in genetic disease we have mapped the NF-κB (NFKB2) and IκB/MAD-3 (NFKBI) loci in a panel of somatic cell hybrids to chromosomes 4 and 14, respectively. Amplification of the 3′ untranslated region of NFKBI allows the detection of three independent polymorphisms within 410 bp. In combination these polymorphisms were informative in 27 of 36 CEPH families and allowed the gene to be placed onto the linkage map of chromosome 14, between the D14S32 and D14S42 markers.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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