Biology Faculty Articles

Title

Polymorphic Admixture Typing in Human Ethnic Populations

Document Type

Article

Publication Date

10-1994

Publication Title

American Journal of Human Genetics

ISSN

0002-9297

Volume

55

Issue/No.

4

First Page

788

Last Page

808

Abstract

A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome. Probes from each locus were used in a Southern blot survey of allele frequency distribution for four human ethnic groups: Caucasian, African American, Asian (Chinese), and American Indian (Cheyenne). Nearly all RFLP loci were polymorphic in each group, albeit with a broad range of differing allele frequencies (δ). The distribution of frequency differences (δ values) was used for three purposes: (1) to provide estimates for genetic distance (differentiation) among these ethnic groups, (2) to revisit with a large data set the proportion of human genetic variation attributable to differentiation within ethnic groups, and (3) to identify loci with high δ values between recently admixed populations of use in mapping by admixture linkage disequilibrium (MALD). Although most markers display significant allele frequency differences between ethnic groups, the overall genetic distances between ethnic groups were small (.066–.098), and

Comments

©1994 by The American Society of Human Genetics

Additional Comments

PMC1918306

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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